2492429-45-3
Chemical Structure
EGFR/BRAFV600E-IN-1
- CAS No.: 2492429-45-3
- Formula:C24H24ClN3O3
- Molecular Weight:437.92
IUPAC Name: 8-chloro-10-methyl-2-(4-morpholinophenethyl)-2,3-dihydropyrazino[1,2-a]indole-1,4-dione
InChIKey: OOIHXWXWHGUVBG-UHFFFAOYSA-N
SMILES: O=C1N(CCC2=CC=C(N3CCOCC3)C=C2)CC(N4C1=C(C)C5=C4C=CC(Cl)=C5)=O
Biological Activity: EGFR/BRAFV600E-IN-1 (Compound 23) is a potent EGFR and BRAFV600E dual inhibitor with IC50s of 0.08 and 0.15 µM, respectively. EGFR/BRAFV600E-IN-1 induces apoptosis and cell cycle arrest in both pre-G1 and G2/M phases. EGFR/BRAFV600E-IN-1 exhibits antiproliferative activity againist A-549, MCF-7, Panc-1, HT-29 with IC50s of 1.2, 0.79, 1.3, and 1.23 µM, respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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EGFR/BRAFV600E-IN-1 | EGFR/BRAFV600E-IN-1 (Compound 23) is a potent EGFR and BRAFV600E dual inhibitor with IC50s of 0.08 and 0.15 µM, respectively. EGFR/BRAFV600E-IN-1 induces apoptosis and cell cycle arrest in both pre-G1 and G2/M phases. EGFR/BRAFV600E-IN-1 exhibits antiproliferative activity againist A-549, MCF-7, Panc-1, HT-29 with IC50s of 1.2, 0.79, 1.3, and 1.23 µM, respectively. | |||||||||||||||||||||
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