2492436-35-6
Chemical Structure
Antitrypanosomal agent 6
- CAS No.: 2492436-35-6
- Formula:C22H29Cl2N5O
- Molecular Weight:450.40
IUPAC Name: 2-(4-(5-(4,5-dihydro-1H-imidazol-2-yl)-1H-benzo[d]imidazol-2-yl)phenoxy)-N,N-diethylethan-1-amine dihydrochloride
InChIKey: KQJYSXPRZQAQLU-UHFFFAOYSA-N
SMILES: CCN(CCOC1=CC=C(C2=NC3=CC(C4=NCCN4)=CC=C3N2)C=C1)CC.[H]Cl.[H]Cl
Biological Activity: Antitrypanosomal agent 6 (compound 18a) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 6 is > 2-fold more potent against Trypanosoma brucei (T. brucei) than Nifurtimox, with an IC50 value of 0.47 μM. Antitrypanosomal agent 6 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA[1].
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Antitrypanosomal agent 6 | Antitrypanosomal agent 6 (compound 18a) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 6 is > 2-fold more potent against Trypanosoma brucei (T. brucei) than Nifurtimox, with an IC50 value of 0.47 μM. Antitrypanosomal agent 6 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA. | |||||||||||||||||||||
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