2494001-21-5
2494001-21-5
Chemical Structure
PARP1-IN-10
- CAS No.: 2494001-21-5
- Formula:C20H23N3O5
- Molecular Weight:385.41
IUPAC Name: 1,3-dimethyl-5-(4-(2-oxo-2-(piperidin-1-yl)ethoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
InChIKey: VKLCODKLVUQTBY-UHFFFAOYSA-N
SMILES: O=C1/C(C(N(C)C(N1C)=O)=O)=C\C2=CC=C(C=C2)OCC(N3CCCCC3)=O
Biological Activity: PARP1-IN-10 (compound 12c) is a no-cytotoxicity and potent PARP1 inhibitor with an IC50 value of 50.62 nM in vitro. PARP1-IN-10 causes cell cycle arrest at G2/M phase and apoptosis, and enhances the cytotoxicity of temozolomide (TMZ) [1].
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PARP1-IN-10 | PARP1-IN-10 (compound 12c) is a no-cytotoxicity and potent PARP1 inhibitor with an IC50 value of 50.62 nM in vitro. PARP1-IN-10 causes cell cycle arrest at G2/M phase and apoptosis, and enhances the cytotoxicity of temozolomide (TMZ) . | |||||||||||||||||||||
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