2499664-52-5
2499664-52-5
Chemical Structure
STM3006
- CAS No.: 2499664-52-5
- Formula:C25H27BrN8
- Molecular Weight:519.44
InChIKey: RXIOMUYKKTZDFQ-UHFFFAOYSA-N
SMILES: BrC1=CC(C2=CN(CC3=CN4C=C(CN5CCC(C)(CC5)C)C=CC4=N3)N=N2)=C6C=NNC6=C1
Biological Activity: STM3006 is a highly potent, selective, and orally active inhibitor of METTL3 (IC50: 5 nM). STM3006 can reduce the m6A level, promote the formation of dsRNA, trigger a cell-intrinsic interferon response, and enhance the killing effect of T cells on tumors. STM3006 has anti-tumor activity, and its combination with anti-PD-1 immunotherapy yields better results[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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STM3006 | 99.79% | STM3006 is a highly potent, selective, and orally active inhibitor of METTL3 (IC50: 5 nM). STM3006 can reduce the m6A level, promote the formation of dsRNA, trigger a cell-intrinsic interferon response, and enhance the killing effect of T cells on tumors. STM3006 has anti-tumor activity, and its combination with anti-PD-1 immunotherapy yields better results. | ||||||||||||||||||||
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References
- [1]. Andrew A Guirguis, et al. Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity.Cancer Discov. 2023 Oct 5;13(10):2228-2247. [Content Brief]
- [2]. Brichkina A, et al. Methyltransferase-like 3 (METTL3) inhibition potentiates anti-tumor immunity: a novel strategy for improving anti-PD1 therapy. Signal Transduct Target Ther. 2023 Dec 11;8(1):448. [Content Brief]
