2503-26-6
Chemical Structure
Destruxin B
- CAS No.: 2503-26-6
- Formula:C32H55N5O7
- Molecular Weight:621.81
IUPAC Name: (3S,6S,9S,16R,21aS)-3-((S)-sec-butyl)-16-isobutyl-6-isopropyl-3,5,8,9,21a-pentamethyldodecahydropyrrolo[1,2-d][1]oxa[4,7,10,13,16]pentaazacyclononadecine-1,4,7,10,14,17(11H,16H)-hexaone
InChIKey: XMKZYWLIQUJHIT-NSIJXKKGSA-N
SMILES: O=C(N[C@]([C@@H](C)CC)(C)C(N(C)[C@@H](C(C)C)C(N(C)[C@@H](C)C(NCC1)=O)=O)=O)[C@@](CCC2)(C)N2C([C@@H](CC(C)C)OC1=O)=O
Biological Activity: Destruxin B, isolated from entomopathogenic fungus Metarhizium anisopliae, is one of the cyclodepsipeptides with insecticidal and anticancer activities. Destruxin B induces apoptosis via a Bcl-2 Family-dependent mitochondrial pathway in human nonsmall cell lung cancer cells[1]. Destruxin B significantly activates caspase-3 and reduces tumor cell proliferation through caspase-mediated apoptosis, not only in vitro but also in vivo[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Destruxin B | 99.35% | Destruxin B, isolated from entomopathogenic fungus Metarhizium anisopliae, is one of the cyclodepsipeptides with insecticidal and anticancer activities. Destruxin B induces apoptosis via a Bcl-2 Family-dependent mitochondrial pathway in human nonsmall cell lung cancer cells. Destruxin B significantly activates caspase-3 and reduces tumor cell proliferation through caspase-mediated apoptosis, not only in vitro but also in vivo. | ||||||||||||||||||||
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References
- [1]. Wu CC, et al. Destruxin B Isolated from Entomopathogenic Fungus Metarhizium anisopliae Induces Apoptosis via a Bcl-2 Family-Dependent Mitochondrial Pathway in Human NonsmallCell Lung Cancer Cells. Evid Based Complement Alternat Med. 2013;2013:548929.
- [2]. Lee YP, et al. In vitro and in vivo anticancer effects of destruxin B on human colorectal cancer. Anticancer Res. 2012 Jul;32(7):2735-45. [Content Brief]
