2503018-29-7
Chemical Structure
INY-05-040
- CAS No.: 2503018-29-7
- Formula:C55H76ClN9O6S
- Molecular Weight:1026.77
InChIKey: GMYCIJOMBQWJAG-CCLXREQOSA-N
SMILES: C[C@H]1C2=C(N3CCN(CC3)C([C@@H](C4=CC=C(C=C4)Cl)CNCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O)=O)N=CN=C2[C@@H](C1)O
Biological Activity: INY-05-040 is an AKT degrader that can selectively and quickly degrade all three AKT isoforms. INY-05-040 exhibits anti-cancer activity. INY-05-040 can inhibit downstream signaling and cell proliferation in 288 cancer cell lines. INY-05-040 can suppress AKT signaling and induces the stress mitogen-activated protein kinase (MAPK) c-Jun N-terminal kinase (JNK). INY-05-040 is effective for breast cancer lines with a low-baseline activation of stress MAPK pathway. INY-05-040 can be studied for anti-cancer research[1][2][3].
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INY-05-040 | 98.54% | INY-05-040 is an AKT degrader that can selectively and quickly degrade all three AKT isoforms. INY-05-040 exhibits anti-cancer activity. INY-05-040 can inhibit downstream signaling and cell proliferation in 288 cancer cell lines. INY-05-040 can suppress AKT signaling and induces the stress mitogen-activated protein kinase (MAPK) c-Jun N-terminal kinase (JNK). INY-05-040 is effective for breast cancer lines with a low-baseline activation of stress MAPK pathway. INY-05-040 can be studied for anti-cancer research. | ||||||||||||||||||||
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References
- [1]. Erickson E C, et al. Multi-omic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation[J]. bioRxiv, 2022: 2022.10. 11.511726.
- [2]. Chen, C., et al., (2024). Down-Regulation of AKT Proteins Slows the Growth of Mutant-KRAS Pancreatic Tumors. Cells, 13(12), 1061. [Content Brief]
- [3]. Wu, Y., et al., (2025). Pharmacodynamics of Akt drugs revealed by a kinase-modulated bioluminescent indicator. Nature chemical biology, 21(8), 1194–1204. [Content Brief]
