250386-15-3
Chemical Structure
Apadenoson
Synonym(s): BMS 068645; DWH 146e
- CAS No.: 250386-15-3
- Formula:C23H30N6O6
- Molecular Weight:486.52
IUPAC Name: methyl (1R,4r)-4-(3-(6-amino-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-2-yl)prop-2-yn-1-yl)cyclohexane-1-carboxylate
InChIKey: FLEVIENZILQUKB-XTWQNQIISA-N
SMILES: NC1=C2C(N([C@@H]3O[C@H](C(NCC)=O)[C@@H](O)[C@H]3O)C=N2)=NC(C#CC[C@H]4CC[C@H](C(OC)=O)CC4)=N1
Biological Activity: Apadenoson (BMS 068645) is a selective A2A adenosine receptor agonist and coronary vasodilator with a Ki of 0.5 nM for hA2AAR. Apadenoson induces anti-inflammatory signaling and reduces cytokine production. Apadenoson decreases weight loss in SARS-CoV-2-infected K18-hACE2 mice. Apadenoson exerts potent anti-inflammatory activity. Apadenoson can be used for research on COVID-19 and inflammatory bowel disease[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Apadenoson | 99.05% | Apadenoson (BMS 068645) is a selective A2A adenosine receptor agonist and coronary vasodilator with a Ki of 0.5 nM for hA2AAR. Apadenoson induces anti-inflammatory signaling and reduces cytokine production. Apadenoson decreases weight loss in SARS-CoV-2-infected K18-hACE2 mice. Apadenoson exerts potent anti-inflammatory activity. Apadenoson can be used for research on COVID-19 and inflammatory bowel disease. | ||||||||||||||||||||
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References
- [1]. Preti D, et al. Design, synthesis, and biological evaluation of novel 2-((2-(4-(substituted)phenylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamidoadenosines as potent and selective agonists of the A2A adenosine receptor. J Med Chem. 2015 Apr 9;58(7):3253-67. [Content Brief]
- [2]. Antoniu SA, et al. Discontinued drugs for pulmonary, allergy, gastrointestinal, arthritis (2012). Expert opinion on investigational drugs. 2013 Nov;22(11):1453-64. [Content Brief]
- [3]. Hong Y, Bonacorsi Jr S J, Tian Y, et al. Synthesis of [1, 2‐3H] ethylamine hydrochloride and [3H]‐labeled apadenoson for a human ADME study[J]. Journal of Labelled Compounds and Radiopharmaceuticals: The Official Journal of the International Isotope Society, 2008, 51(2): 113-117.
- [4]. Mann BJ, et al. Improved survival of SARS COV-2-infected K18- mice treated with adenosine AR agonist. Heliyon. 2023 Aug;9(8):e19226.
- [5]. Odashima M, et al. Activation of A2A adenosine receptor attenuates intestinal inflammation in animal models of inflammatory bowel disease. Gastroenterology. 2005 Jul;129(1):26-33.
