250780-40-6
Chemical Structure
Telmisartan acyl-β-D-glucuronide
- CAS No.: 250780-40-6
- Formula:C39H38N4O8
- Molecular Weight:690.74
IUPAC Name: (2S,3S,4S,5R,6S)-6-((4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carbonyl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid
InChIKey: RCOBUBSULFIXAR-QQPFWGBFSA-N
SMILES: CCCC(N(C1=CC(C2=NC3=CC=CC=C3N2C)=C4)CC5=CC=C(C6=C(C=CC=C6)C(O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)C(O)=O)=O)C=C5)=NC1=C4C
Biological Activity: Telmisartan acyl-β-D-glucuronide is an acyl-β-D-glucuronide and a metabolite of Telmisartan (HY-13955). Telmisartan acyl-β-D-glucuronide can be converted back to Telmisartan upon incubation with Glucuronidase. Partial acyl migration of Telmisartan acyl-β-D-glucuronide occurs under physiological conditions[1][2].
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Telmisartan acyl-β-D-glucuronide | Telmisartan acyl-β-D-glucuronide is an acyl-β-D-glucuronide and a metabolite of Telmisartan (HY-13955). Telmisartan acyl-β-D-glucuronide can be converted back to Telmisartan upon incubation with Glucuronidase. Partial acyl migration of Telmisartan acyl-β-D-glucuronide occurs under physiological conditions. | |||||||||||||||||||||
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References
- [1]. Niyonsaba E, et al. Differentiation of Deprotonated Acyl-, N-, and O-Glucuronide Drug Metabolites by Using Tandem Mass Spectrometry Based on Gas-Phase Ion-Molecule Reactions Followed by Collision-Activated Dissociation. Anal Chem. 2019;91(17):11388-11396. [Content Brief]
- [2]. Stangier J, et al. Absorption, metabolism, and excretion of intravenously and orally administered [14C]telmisartan in healthy volunteers. J Clin Pharmacol. 2000;40(12 Pt 1):1312-1322. [Content Brief]
