25090-71-5
Chemical Structure
12-Deoxyphorbol-13-isobutyrate-20-acetate
- CAS No.: 25090-71-5
- Formula:C26H36O7
- Molecular Weight:460.56
InChIKey: MTXOHECJOIIIJM-PHFLZNSYSA-N
SMILES: CC(C)C(O[C@@]12[C@@]([C@@]3([H])[C@]([C@@H](C2)C)([C@@]4([H])[C@](CC(COC(C)=O)=C3)(C(C(C)=C4)=O)O)O)([H])C1(C)C)=O
Biological Activity: 12-Deoxyphorbol-13-isobutyrate-20-acetate is a 12-deoxy-phorbol diterpene ester. 12-Deoxyphorbol-13-isobutyrate-20-acetate is a protein kinase C (PKC) agonist that activates protein kinase C to phosphorylate troponin I and troponin T. 12-Deoxyphorbol-13-isobutyrate-20-acetate induces skin irritation and necrosis in mice without cocarcinogenic activity. 12-Deoxyphorbol-13-isobutyrate-20-acetate inhibits Aspergillus carbonarius growth. 12-Deoxyphorbol-13-isobutyrate-20-acetate supports research on heart failure, cardiomyopathies and fungal infection[1][2][3].
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12-Deoxyphorbol-13-isobutyrate-20-acetate | 12-Deoxyphorbol-13-isobutyrate-20-acetate is a 12-deoxy-phorbol diterpene ester. 12-Deoxyphorbol-13-isobutyrate-20-acetate is a protein kinase C (PKC) agonist that activates protein kinase C to phosphorylate troponin I and troponin T. 12-Deoxyphorbol-13-isobutyrate-20-acetate induces skin irritation and necrosis in mice without cocarcinogenic activity. 12-Deoxyphorbol-13-isobutyrate-20-acetate inhibits Aspergillus carbonarius growth. 12-Deoxyphorbol-13-isobutyrate-20-acetate supports research on heart failure, cardiomyopathies and fungal infection. | |||||||||||||||||||||
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References
- [1]. Gwathmey JK, et al. Effect of protein kinase C activation on sarcoplasmic reticulum function and apparent myofibrillar Ca2+ sensitivity in intact and skinned muscles from normal and diseased human myocardium. Circ Res. 1990;67(3):744-752. [Content Brief]
- [2]. Hergenhahn M, et al. Diterpene esters from 'Euphorbium' and their irritant and cocarcinogenic activity. Experientia. 1974 Dec 15;30(12):1438-40. [Content Brief]
- [3]. Ourhzif EM, et al. Antifungal and Cytotoxic Activity of Diterpenes and Bisnorsesquiterpenoides from the Latex of Euphorbia resinifera Berg. Molecules. 2022 Aug 16;27(16):5234. [Content Brief]
