2511632-55-4
2511632-55-4
Chemical Structure
PDE4B/7A-IN-2
- CAS No.: 2511632-55-4
- Formula:C25H35N3O2
- Molecular Weight:409.56
IUPAC Name: N-(4-isopropylphenyl)-5-(4-(2-methoxyphenyl)piperazin-1-yl)pentanamide
InChIKey: QYHJCCPZZFERTO-UHFFFAOYSA-N
SMILES: COC1=C(C=CC=C1)N2CCN(CC2)CCCCC(NC3=CC=C(C=C3)C(C)C)=O
Biological Activity: 5-HT1A/5-HT7 receptor antagonist (5-HT1A Ki = 8 nM, Kb = 0.04 nM; 5-HT7 Ki = 451 nM, Kb = 460 nM) with PDE4B/PDE7A inhibitory activity (PDE4B IC50 = 80.4 μM; PDE7A IC50 = 151.3 μM) , its antidepressant like effect is stronger than that of escitalopram as a reference agent.
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PDE4B/7A-IN-2 | 5-HT1A/5-HT7 receptor antagonist (5-HT1A Ki = 8 nM, Kb = 0.04 nM; 5-HT7 Ki = 451 nM, Kb = 460 nM) with PDE4B/PDE7A inhibitory activity (PDE4B IC50 = 80.4 μM; PDE7A IC50 = 151.3 μM) , its antidepressant like effect is stronger than that of escitalopram as a reference agent. | |||||||||||||||||||||
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