2513461-95-3
Chemical Structure
Topoisomerase I inhibitor 5
- CAS No.: 2513461-95-3
- Formula:C24H24N2O2
- Molecular Weight:372.46
IUPAC Name: 4-(2-(2-methylpiperidin-1-yl)ethoxy)-7H-dibenzo[de,h]quinolin-7-one
InChIKey: HGOZQJNNPSXGNT-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC=C12)C3=CC=C(OCCN4C(C)CCCC4)C5=CC=NC2=C53
Biological Activity: Topoisomerase I inhibitor 5 is an effective topoisomerase inhibitor with IC50 value of. Topoisomerase I inhibitor 5 can interfere with DNA and significantly inhibit the activity of Topoisomerase I. Topoisomerase I inhibitor 5 can arrest cell cycle at the G1 phase and induce MCF-7 cells apoptosis. Topoisomerase I inhibitor 5 has potency in reversing P-gp-mediated resistance to Adriamycin[1].
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Topoisomerase I inhibitor 5 | Topoisomerase I inhibitor 5 is an effective topoisomerase inhibitor with IC50 value of. Topoisomerase I inhibitor 5 can interfere with DNA and significantly inhibit the activity of Topoisomerase I. Topoisomerase I inhibitor 5 can arrest cell cycle at the G1 phase and induce MCF-7 cells apoptosis. Topoisomerase I inhibitor 5 has potency in reversing P-gp-mediated resistance to Adriamycin. | |||||||||||||||||||||
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