2517771-89-8
2517771-89-8
Chemical Structure
GSK2945 hydrochloride
- CAS No.: 2517771-89-8
- Formula:C20H19Cl3N2O2S
- Molecular Weight:457.80
IUPAC Name: N-(4-chloro-2-methylbenzyl)-N-(4-chlorobenzyl)-1-(5-nitrothiophen-2-yl)methanamine hydrochloride
InChIKey: HRNMOPTYOFRUFF-UHFFFAOYSA-N
SMILES: O=[N+](C1=CC=C(CN(CC2=CC=C(Cl)C=C2C)CC3=CC=C(Cl)C=C3)S1)[O-].Cl
Biological Activity: GSK2945 hydrochloride is a class of tertiary amine, and is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC50s of 21.5 μM and 20.8 μM, respectively. GSK2945 hydrochloride enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GSK2945 hydrochloride | 98.49% | GSK2945 hydrochloride is a class of tertiary amine, and is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC50s of 21.5 μM and 20.8 μM, respectively. GSK2945 hydrochloride enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism. | ||||||||||||||||||||
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ARL 17477 | 98.88% | ARL 17477 is a blood-brain barrier-penetrant selective neuronal nitric oxide synthase (nNOS) inhibitor with an IC50 of 1 μM. ARL 17477 reduces nitric oxide production and activates TFEB and lysosomal biogenesis, induces lysosomal membrane permeabilization, but inhibits autophagy-lysosomal function, autophagic flux, protein aggregate clearance, and proliferation. ARL 17477 induces ERK hyperphosphorylation and slight AKT inhibition. ARL 17477 exhibits NOS1 -independent anticancer activity against multiple cancer cells. ARL 17477 inhibits xenograft tumor growth in vivo. ARL 17477 can be used in research on colon cancer, non-small cell lung cancer, osteosarcoma, pancreatic cancer, arterial occlusion, and pain. | ||||||||||||||||||||
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IHR-1 | 98.05% | IHR-1 is a cell membrane impermeable Smo antagonist. | ||||||||||||||||||||
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GSK2945 | GSK2945 is a class of tertiary amine, and is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC50s of 21.5 μM and 20.8 μM, respectively. GSK2945 enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism. | |||||||||||||||||||||
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GSK4112 | 99.31% | GSK4112 (SR6452) is a Rev-erbα agonist with an EC50 value of 0.4 μM. GSK4112 can be used as a chemical tool to probe the function of Rev-erbα in transcriptional repression, regulation of circadian biology, and metabolic pathways. | ||||||||||||||||||||
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HDAC1/MAO-B-IN-1 | HDAC1/MAO-B-IN-1 is a potent, selective and cross the blood-brain barrier HDAC1/MAO-B inhibitor with IC50 values of 21.4 nM and 99.0 nM for HDAC1 and MAO-B, respectively. HDAC1/MAO-B-IN-1 has the potential for the research of Alzheimer’s disease. | |||||||||||||||||||||
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DRB18 | 99.58% | DRB18 is a potent pan-class GLUT inhibitor. DRB18 alters energy-related metabolism in A549 cells by changing the abundance of metabolites in glucose-related pathways. DRB18 can eventually lead to G1/S phase arrest and increase oxidative stress and necrotic cell death. DRB18 has anti-tumor activity. | ||||||||||||||||||||
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SR9011 | 99.78% | SR9011 is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. | ||||||||||||||||||||
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SR9011 hydrochloride | 98.97% | SR9011 hydrochloride is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. | ||||||||||||||||||||
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SR9009 | 99.32% | SR9009 is a REV-ERBα/β agonist with IC50s of 670 nM and 800 nM for REV-ERBα and REV-ERBβ, respectively. | ||||||||||||||||||||
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4,4′,4′′-[Nitrilotris(methylene)]tris[benzoic acid] | 4,4′,4′′-[Nitrilotris(methylene)]tris[benzoic acid] is a metal-organic framework (MOF). | |||||||||||||||||||||
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