2521560-46-1
Chemical Structure
Tubulin polymerization-IN-30
- CAS No.: 2521560-46-1
- Formula:C22H25N5O3
- Molecular Weight:407.47
IUPAC Name: (4-(3,5-dimethoxyphenyl)piperazin-1-yl)(5-methyl-4-phenyl-4H-1,2,4-triazol-3-yl)methanone
InChIKey: HYEAEXMHPMEDAI-UHFFFAOYSA-N
SMILES: O=C(C1=NN=C(C)N1C2=CC=CC=C2)N3CCN(C4=CC(OC)=CC(OC)=C4)CC3
Biological Activity: Tubulin polymerization-IN-30 (compound 6e) is a potent Tubulin polymerization inhibitor. Tubulin polymerization-IN-30 is a colchicine binding site inhibitor. Tubulin polymerization-IN-30 can disrupt intracellular microtubule organization, arrest cell cycle at the G2/M phase. Tubulin polymerization-IN-30 exhibits the high potency against the cancer cell lines including SGC-7901, A549 and HeLa, with IC50 values of 2.16, 2.21, and 0.403 μM[1].
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Tubulin polymerization-IN-30 | Tubulin polymerization-IN-30 (compound 6e) is a potent Tubulin polymerization inhibitor. Tubulin polymerization-IN-30 is a colchicine binding site inhibitor. Tubulin polymerization-IN-30 can disrupt intracellular microtubule organization, arrest cell cycle at the G2/M phase. Tubulin polymerization-IN-30 exhibits the high potency against the cancer cell lines including SGC-7901, A549 and HeLa, with IC50 values of 2.16, 2.21, and 0.403 μM. | |||||||||||||||||||||
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