2521624-67-7
2521624-67-7
Chemical Structure
GSK-3β inhibitor 17
- CAS No.: 2521624-67-7
- Formula:C26H18F3N5O6S2
- Molecular Weight:617.58
InChIKey: AOMYEUVOFIVOFA-UHFFFAOYSA-N
SMILES: COC(C1=CC=C(S1)S(=O)(NC2=CC=C(C=C2)C3=NC(C4=CC(NC5=CC=C(C=C5)OC(F)(F)F)=NC=C4)=NO3)=O)=O
Biological Activity: GSK-3β inhibitor 17 (compound 5 n) is a potent GSK-3β inhibitor. GSK-3β inhibitor 17 decreases cisplatin (HY-17394) induced p-p65, KIM-1 protein and mRNA expression. GSK-3β inhibitor 17 decreases cisplatin induced TNF-α, IL-1β, IL-6 and MCP-1 mRNA expression. GSK-3β inhibitor 17 shows anti-inflammation effect and has the potential for the research of acute kidney injury[1].
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GSK-3β inhibitor 17 | GSK-3β inhibitor 17 (compound 5 n) is a potent GSK-3β inhibitor. GSK-3β inhibitor 17 decreases cisplatin (HY-17394) induced p-p65, KIM-1 protein and mRNA expression. GSK-3β inhibitor 17 decreases cisplatin induced TNF-α, IL-1β, IL-6 and MCP-1 mRNA expression. GSK-3β inhibitor 17 shows anti-inflammation effect and has the potential for the research of acute kidney injury. | |||||||||||||||||||||
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