253688-61-8
253688-61-8
Chemical Structure
Desmethyl Bosentan
Synonym(s): Ro 47-8634
- CAS No.: 253688-61-8
- Formula:C26H27N5O6S
- Molecular Weight:537.59
IUPAC Name: 4-(tert-butyl)-N-(6-(2-hydroxyethoxy)-5-(2-hydroxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide
InChIKey: STTLKJGYAWXIPP-UHFFFAOYSA-N
SMILES: O=S(NC1=C(OC2=C(O)C=CC=C2)C(OCCO)=NC(C3=NC=CC=N3)=N1)(C4=CC=C(C(C)(C)C)C=C4)=O
Biological Activity: Desmethyl bosentan is an active metabolite of the endothelin receptor antagonist bosentan (HY-A0013).1 Desmethyl bosentan (25 μM) activates the pregnane X receptor (PXR) in CV-1 monkey kidney cells expressing the human receptor in a reporter assay.
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Desmethyl Bosentan | Desmethyl bosentan is an active metabolite of the endothelin receptor antagonist bosentan (HY-A0013).1 Desmethyl bosentan (25 μM) activates the pregnane X receptor (PXR) in CV-1 monkey kidney cells expressing the human receptor in a reporter assay. | |||||||||||||||||||||
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