25371-96-4
25371-96-4
Chemical Structure
TRIM
- CAS No.: 25371-96-4
- Formula:C10H7F3N2
- Molecular Weight:212.17
IUPAC Name: 1-(2-(trifluoromethyl)phenyl)-1H-imidazole
InChIKey: WZBWBNCQUTXYEL-UHFFFAOYSA-N
SMILES: FC(C1=CC=CC=C1N2C=CN=C2)(F)F
Biological Activity: TRIM is a potent nitric oxide synthase inhibitor. TRIM inhibits mouse cerebellar nNOS and rat lung iNOS in vitro with IC50 values of 28.2 and 27.0 µM, respectively. Antidepressant- and anxiolytic-like effects[1][2].
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TRIM | 99.80% | TRIM is a potent nitric oxide synthase inhibitor. TRIM inhibits mouse cerebellar nNOS and rat lung iNOS in vitro with IC50 values of 28.2 and 27.0 µM, respectively. Antidepressant- and anxiolytic-like effects. | ||||||||||||||||||||
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References
- [1]. Handy RL, et al. The antinociceptive effect of 1-(2-trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse. Br J Pharmacol. 1995;116(5):2349-2350. [Content Brief]
- [2]. Volke V, et al. Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice. Behav Brain Res. 2003;140(1-2):141-147. [Content Brief]
