2540915-70-4
2540915-70-4
Chemical Structure
NHTD
- CAS No.: 2540915-70-4
- Formula:C24H26N2O5
- Molecular Weight:422.47
InChIKey: PPMLIPWTLQQLCB-BRJLIKDPSA-N
SMILES: CC(C)(C)C1=C(O)C(/C=N/NC(C2=C(O)C=C(O)C=C2)=O)=C(C(CCCC3)=C3O4)C4=C1
Biological Activity: NHTD is a KRAS-PDEδ inhibitor. NHTD targets the prenyl-binding pocket of PDEδ, altering the cellular localization of KRAS, thereby inhibiting the proliferation of KRAS-mutant cancer cells and inducing apoptosis. NHTD can be used for research on KRAS-driven non-small cell lung cancer (NSCLC)[1].
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NHTD | NHTD is a KRAS-PDEδ inhibitor. NHTD targets the prenyl-binding pocket of PDEδ, altering the cellular localization of KRAS, thereby inhibiting the proliferation of KRAS-mutant cancer cells and inducing apoptosis. NHTD can be used for research on KRAS-driven non-small cell lung cancer (NSCLC). | |||||||||||||||||||||
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