2543578-57-8
2543578-57-8
Chemical Structure
DCN1-IN-2
- CAS No.: 2543578-57-8
- Formula:C18H14ClF3N4OS
- Molecular Weight:426.84
InChIKey: AHJFGEVQCAXTEI-UHFFFAOYSA-N
SMILES: O=C(CCN1C(NN=C1C2=CC=C(Cl)C=C2)=S)NC3=CC=CC(C(F)(F)F)=C3
Biological Activity:
DCN1-IN-2 is a DCN1 inhibitor with an IC50 value of 2.96 nM. DCN1-IN-2 can alleviate Ang II/TGFβ-induced activation of cardiac fibroblasts. DCN1-IN-2 can reduce ISO-induced cardiac fibrosis and remodeling in mice by selectively inhibiting cullin 3[1].
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DCN1-IN-2 | DCN1-IN-2 is a DCN1 inhibitor with an IC50 value of 2.96 nM. DCN1-IN-2 can alleviate Ang II/TGFβ-induced activation of cardiac fibroblasts. DCN1-IN-2 can reduce ISO-induced cardiac fibrosis and remodeling in mice by selectively inhibiting cullin 3. |
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