254737-87-6
Chemical Structure
BMS-248360
- CAS No.: 254737-87-6
- Formula:C36H45N5O5S
- Molecular Weight:659.84
IUPAC Name: 4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-2'-((3,3-dimethyl-2-oxopyrrolidin-1-yl)methyl)-N-(3,4-dimethylisoxazol-5-yl)-[1,1'-biphenyl]-2-sulfonamide
InChIKey: NBDFXMDYBLSGLX-UHFFFAOYSA-N
SMILES: O=S(C1=CC=CC=C1C2=CC=C(CN3C(CCCC)=NC4(CCCC4)C3=O)C=C2CN5C(C(C)(C)CC5)=O)(NC6=C(C)C(C)=NO6)=O
Biological Activity: BMS-248360 is a potent and orally active dual antagonist of both angiotensin II receptor (AT1) and endothelin A (ETA) receptor, with Kis of 10 nM and 1.9 nM for hAT1 and hETA receptor, respectively. BMS-248360 displays hypertensive effects[1].
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BMS-248360 | BMS-248360 is a potent and orally active dual antagonist of both angiotensin II receptor (AT1) and endothelin A (ETA) receptor, with Kis of 10 nM and 1.9 nM for hAT1 and hETA receptor, respectively. BMS-248360 displays hypertensive effects. | |||||||||||||||||||||
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