2549046-46-8
2549046-46-8
Chemical Structure
KS-58
- CAS No.: 2549046-46-8
- Formula:C64H89FN12O14S2
- Molecular Weight:1333.59
SMILES: O=C([C@H](CO)NC([C@H](CCCCCCC)NC([C@H]1NC([C@H](CCCC)NC([C@@H]2CCCN2C(CCNC3=O)=O)=O)=O)=O)=O)N[C@H](C(N[C@H](C(N4[C@H](C(N[C@@H](CC5=CNC6=C5C=CC=C6)C(N[C@@H]3CSCCCSC1)=O)=O)CCC4)=O)CC(O)=O)=O)CC7=CC=C(F)C=C7
Biological Activity: KS-58 is a KRpep-2d (HY-P3277) derivative. KS-58 is a K-Ras (G12D) inhibitory peptide that selectively binds K-Ras. KS-58 can enter cells and block intracellular Ras interaction with effector proteins. KS-58 inhibits the proliferation of tumor cells and has antitumor activity[1][2].
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KS-58 | KS-58 is a KRpep-2d (HY-P3277) derivative. KS-58 is a K-Ras (G12D) inhibitory peptide that selectively binds K-Ras. KS-58 can enter cells and block intracellular Ras interaction with effector proteins. KS-58 inhibits the proliferation of tumor cells and has antitumor activity. | |||||||||||||||||||||
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References
- [1]. Sakamoto K, et al. Nanoformulation of the K-Ras(G12D)-inhibitory peptide KS-58 suppresses colorectal and pancreatic cancer-derived tumors. Sci Rep. 2023 Jan 10;13(1):518. [Content Brief]
- [2]. Sakamoto K, et al Generation of KS-58 as the first K-Ras(G12D)-inhibitory peptide presenting anti-cancer activity in vivo. Sci Rep. 2020 Dec 10;10(1):21671. [Content Brief]
