2549192-10-9
Chemical Structure
EGFR-IN-113
- CAS No.: 2549192-10-9
- Formula:C31H32ClFN4O7
- Molecular Weight:627.06
IUPAC Name: 3-((4-((3-chloro-4-fluorophenyl)amino)-6-(3-morpholinopropoxy)quinazolin-7-yl)oxy)propyl 3,5-dihydroxybenzoate
InChIKey: ZRKPRXHTOXPUES-UHFFFAOYSA-N
SMILES: O=C(C1=CC(O)=CC(O)=C1)OCCCOC2=CC3=NC=NC(NC4=CC=C(C(Cl)=C4)F)=C3C=C2OCCCN5CCOCC5
Biological Activity: EGFR-IN-113 (compound II-1) is an EGFR kinase inhibitor with an IC50 of 14.79 μM. EGFR-IN-113 can induce apoptosis and inhibit cell proliferation by downregulating Akt and Erk1/2 signaling. EGFR-IN-113 can be used for research in EGFR-driven cancers, such as lung cancer, pancreatic cancer, and breast cancer[1].
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EGFR-IN-113 | EGFR-IN-113 (compound II-1) is an EGFR kinase inhibitor with an IC50 of 14.79 μM. EGFR-IN-113 can induce apoptosis and inhibit cell proliferation by downregulating Akt and Erk1/2 signaling. EGFR-IN-113 can be used for research in EGFR-driven cancers, such as lung cancer, pancreatic cancer, and breast cancer. | |||||||||||||||||||||
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