2550393-38-7
2550393-38-7
Chemical Structure
TG11-77 hydrochloride
- CAS No.: 2550393-38-7
- Formula:C23H25ClN6O
- Molecular Weight:436.94
InChIKey: KNHQNXHZXZHWSS-UHFFFAOYSA-N
SMILES: O=C(C1=CN=C(NC2=CC(C)=CC(C)=N2)N=C1)NCCC3=C(C)NC4=C3C=CC=C4.Cl
Biological Activity: TG11-77 hydrochloride is a potent, selective, orally active and brain permeant EP2 antagonist, with a KB of 9.7 nM. TG11-77 hydrochloride inhibits PGE2-induced human EP2 receptor activation. TG11-77 hydrochloride exhibits anti-inflammatory activity. TG11-77 hydrochloride reduces delayed mortality and memory deficit[1][2].
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TG11-77 hydrochloride | TG11-77 hydrochloride is a potent, selective, orally active and brain permeant EP2 antagonist, with a KB of 9.7 nM. TG11-77 hydrochloride inhibits PGE2-induced human EP2 receptor activation. TG11-77 hydrochloride exhibits anti-inflammatory activity. TG11-77 hydrochloride reduces delayed mortality and memory deficit. | |||||||||||||||||||||
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References
- [1]. Amaradhi R, et al. Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist for Use in Central Nervous System Disease Models. J Med Chem. 2020 Feb 13;63(3):1032-1050. [Content Brief]
- [2]. Varvel NH, et al. Preclinical development of an EP2 antagonist for post-seizure cognitive deficits. Neuropharmacology. 2023 Feb 15;224:109356. [Content Brief]
