25522-33-2
Chemical Structure
trans-Isoferulic acid
Synonym(s): trans-3-Hydroxy-4-methoxycinnamic acid
- CAS No.: 25522-33-2
- Formula:C10H10O4
- Molecular Weight:194.19
IUPAC Name: (E)-3-(3-hydroxy-4-methoxyphenyl)acrylic acid
InChIKey: QURCVMIEKCOAJU-HWKANZROSA-N
SMILES: O=C(O)/C=C/C1=CC=C(OC)C(O)=C1
Biological Activity: trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid that exhibits anti-inflammatory activity. trans-Isoferulic acid dephosphorylates PI3K/Akt, suppresses LPS (HY-D1056)-induced NF-κB activation, enhances Nrf2 activity, downregulates iNOS and COX-2 expression, induces HO-1 expression, inhibits NO and PGE2 production, and scavenges hydroperoxyl radical. trans-Isoferulic acid can be used for research of inflammatiory diseases[1][2][3].
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trans-Isoferulic acid | 99.93% | trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid that exhibits anti-inflammatory activity. trans-Isoferulic acid dephosphorylates PI3K/Akt, suppresses LPS (HY-D1056)-induced NF-κB activation, enhances Nrf2 activity, downregulates iNOS and COX-2 expression, induces HO-1 expression, inhibits NO and PGE2 production, and scavenges hydroperoxyl radical. trans-Isoferulic acid can be used for research of inflammatiory diseases. | ||||||||||||||||||||
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trans-Isoferulic acid (Standard) | ≥98% | trans-Isoferulic acid (Standard) is the analytical standard of trans-Isoferulic acid. This product is intended for research and analytical applications. trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity.trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1). | ||||||||||||||||||||
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trans-Isoferulic acid-d3 | trans-Isoferulic acid-d3 is the deuterium labeled trans-Isoferulic acid. trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity.trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1). | |||||||||||||||||||||
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References
- [1]. Dilshara MG, et al. Downregulation of NO and PGE2 in LPS-stimulated BV2 microglial cells by trans-isoferulic acid via suppression of PI3K/Akt-dependent NF-κB and activation of Nrf2-mediated HO-1. Int Immunopharmacol. 2014;18(1):203-211. [Content Brief]
- [2]. Sun KH, et al. A new indole-type alkaloid from the roots of Clematis florida var. plena. Nat Prod Res. 2019 Oct;33(20):2925-2931. [Content Brief]
- [3]. Kowalska-Baron A, et al. Theoretical Insight into Antioxidant Mechanisms of Trans-Isoferulic Acid in Aqueous Medium at Different pH. Int J Mol Sci. 2025;26(12):5615. Published 2025 Jun 11. [Content Brief]
