2554618-33-4
Chemical Structure
HIV-1 inhibitor-22
- CAS No.: 2554618-33-4
- Formula:C30H26N6O3S
- Molecular Weight:550.63
IUPAC Name: (E)-N-(4-cyanophenyl)-2-((4-((4-(2-cyanovinyl)-2,6-dimethylphenyl)amino)-6,7-dimethoxyquinazolin-2-yl)thio)acetamide
InChIKey: GIFXBYKFZXYXAH-AATRIKPKSA-N
SMILES: O=C(NC1=CC=C(C#N)C=C1)CSC2=NC(NC3=C(C)C=C(/C=C/C#N)C=C3C)=C4C=C(OC)C(OC)=CC4=N2
Biological Activity: HIV-1 inhibitor-22 (compound 11a) is a potent HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor, with an IC50 value of 3.63 μM for HIV-1 RT. HIV-1 inhibitor-22 has antiretroviral activity against HIV-1 WT and K103N strains with EC50s of 0.304 μM and 0.201 μM, also has low cytotoxicity (CC50 > 227 μM)[1]
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HIV-1 inhibitor-22 | HIV-1 inhibitor-22 (compound 11a) is a potent HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor, with an IC50 value of 3.63 μM for HIV-1 RT. HIV-1 inhibitor-22 has antiretroviral activity against HIV-1 WT and K103N strains with EC50s of 0.304 μM and 0.201 μM, also has low cytotoxicity (CC50 > 227 μM) | |||||||||||||||||||||
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