2554620-04-9
Chemical Structure
HIV-1 inhibitor-21
- CAS No.: 2554620-04-9
- Formula:C28H24N6O2
- Molecular Weight:476.53
IUPAC Name: (E)-4-((4-((4-(2-cyanovinyl)-2,6-dimethylphenyl)amino)-6,7-dimethoxyquinazolin-2-yl)amino)benzonitrile
InChIKey: JZWWKCUXZXWRSL-AATRIKPKSA-N
SMILES: N#CC1=CC=C(NC2=NC(NC3=C(C)C=C(/C=C/C#N)C=C3C)=C4C=C(OC)C(OC)=CC4=N2)C=C1
Biological Activity: HIV-1 inhibitor-21 (compound 9b) is a potent HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor, with an IC50 value of 0.55 μM for HIV-1 RT. HIV-1 inhibitor-21 has antiretroviral activity against HIV-1 WT and K103N strains with EC50s of 12.7 nM and 10.4 nM, and has relatively low cytotoxicity (MT-4 cells CC50 =10.2 μM)[1].
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HIV-1 inhibitor-21 | HIV-1 inhibitor-21 (compound 9b) is a potent HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor, with an IC50 value of 0.55 μM for HIV-1 RT. HIV-1 inhibitor-21 has antiretroviral activity against HIV-1 WT and K103N strains with EC50s of 12.7 nM and 10.4 nM, and has relatively low cytotoxicity (MT-4 cells CC50 =10.2 μM). | |||||||||||||||||||||
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