255730-18-8
255730-18-8
Chemical Structure
Artemisone
Synonym(s): Artemifone; BAY 44-9585
- CAS No.: 255730-18-8
- Formula:C19H31NO6S
- Molecular Weight:401.52
IUPAC Name: 4-((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)thiomorpholine 1,1-dioxide
InChIKey: FDMUNKXWYMSZIR-NQWKWHCYSA-N
SMILES: C[C@H]1[C@H](N2CCS(CC2)(=O)=O)O[C@@]3([H])[C@]45[C@@]([C@H](C)CC[C@]51[H])([H])CC[C@@](O3)(C)OO4
Biological Activity: Artemisone (Artemifone) is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains, with a mean IC50 of 0.83 nM[1]. Artemisone is also a potent inhibitor of human CMV[2].
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Artemisone | 98.0% | Artemisone (Artemifone) is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains, with a mean IC50 of 0.83 nM. Artemisone is also a potent inhibitor of human CMV. | ||||||||||||||||||||
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Artemisone (Standard) | ≥98% | Artemisone (Standard) is the analytical standard of Artemisone. This product is intended for research and analytical applications. Artemisone (Artemifone) is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains, with a mean IC50 of 0.83 nM. Artemisone is also a potent inhibitor of human CMV. | ||||||||||||||||||||
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References
- [1]. Vivas L, et al. Antimalarial efficacy and drug interactions of the novel semi-synthetic endoperoxide artemisone in vitro and in vivo. J Antimicrob Chemother. 2007 Apr;59(4):658-65. [Content Brief]
- [2]. Ruiyuan Cao, et al. Anti-SARS-CoV-2 Potential of Artemisinins In Vitro. ACS Infect. Dis. 2020 Jul.
