2558211-88-2
Chemical Structure
Mito-CS1
- CAS No.: 2558211-88-2
- Formula:C52H63BBrF2N4O3PS4
- Molecular Weight:1080.03
InChIKey: AEDOZLHDOIFGCY-UHFFFAOYSA-N
SMILES: O=C(COC1=CC(C)=C(C2=C3C=CC(N(CCSCCSCC)CCSCCSCC)=[N+]3[B-](F)(N4C(OC)=CC=C24)F)C(C)=C1)NCC[P+](C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7.[Br-]
Biological Activity: Mito-CS1 is a fluorescent probe for imaging and reversible detection of the exchangeable mitochondrial Cu+ pool in living cells. Mito-CS1 combines a Cu+-responsive fluorescent platform with a mitochondria-targeted triphenylphosphonium group, which localizes the probe to mitochondria via a proton gradient. Mito-CS1 contains a thioether-rich receptor for the selective recognition and binding of Cu+, triggering a fluorescence turn-on response by inhibiting photoinduced electron transfer. The apo-form of Mito-CS1 has excitation/emission wavelengths of 555/569 nm, while those of Mito-CS1 after binding to Cu+ are 550/558 nm[1][2][3].
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Mito-CS1 | Mito-CS1 is a fluorescent probe for imaging and reversible detection of the exchangeable mitochondrial Cu+ pool in living cells. Mito-CS1 combines a Cu+-responsive fluorescent platform with a mitochondria-targeted triphenylphosphonium group, which localizes the probe to mitochondria via a proton gradient. Mito-CS1 contains a thioether-rich receptor for the selective recognition and binding of Cu+, triggering a fluorescence turn-on response by inhibiting photoinduced electron transfer. The apo-form of Mito-CS1 has excitation/emission wavelengths of 555/569 nm, while those of Mito-CS1 after binding to Cu+ are 550/558 nm. | |||||||||||||||||||||
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References
- [1]. Dodani SC, et al. A targetable fluorescent sensor reveals that copper-deficient SCO1 and SCO2 patient cells prioritize mitochondrial copper homeostasis. Journal of the American Chemical Society. 2011 Jun 08;133(22):8606-16.
- [2]. Cotruvo JA, et al. Synthetic fluorescent probes for studying copper in biological systems. Chemical Society reviews. 2015 Jul 07;44(13):4400-14. [Content Brief]
- [3]. Dodani S. Development and Applications of New Chemical Tools for Studying the Cell Biology of Metals. UC Berkeley, 2013.
