2559703-06-7
Chemical Structure
Apostatin-1
Synonym(s): Apt-1
- CAS No.: 2559703-06-7
- Formula:C19H27N3OS
- Molecular Weight:345.50
IUPAC Name: N-cycloheptyl-2-((1-methyl-4,5-dihydro-1H-imidazol-2-yl)thio)-2-phenylacetamide
InChIKey: OXBMBNASDMMXSA-UHFFFAOYSA-N
SMILES: O=C(NC1CCCCCC1)C(SC2=NCCN2C)C3=CC=CC=C3
Biological Activity: Apostatin-1 (Apt-1) is a potent TRADD inhibitor. Apostatin-1 can bind with TRADD-N (KD=2.17 μM), disrupting its binding to both TRADD-C and TRAF2. Apostatin-1 modulates the ubiquitination of RIPK1 and beclin 1. Apostatin-1 blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein, or huntingtin[1].
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Apostatin-1 | 99.64% | Apostatin-1 (Apt-1) is a potent TRADD inhibitor. Apostatin-1 can bind with TRADD-N (KD=2.17 μM), disrupting its binding to both TRADD-C and TRAF2. Apostatin-1 modulates the ubiquitination of RIPK1 and beclin 1. Apostatin-1 blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein, or huntingtin. | ||||||||||||||||||||
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