2566-32-7
2566-32-7
Chemical Structure
N-Methyl-DL-valine
Synonym(s): N-Methylvaline
- CAS No.: 2566-32-7
- Formula:C6H13NO2
- Molecular Weight:131.17
IUPAC Name: methylvaline
InChIKey: AKCRVYNORCOYQT-UHFFFAOYSA-N
SMILES: O=C(C(C(C)C)NC)O
Biological Activity: N-Methyl-DL-valine is a valine derivant, is metabolized to cysteine, alanine, tyrosine, tryptophan, citric acid, and succinic acid in the sprout. N-Methyl-DL-valine involves in the modification of monomethyl auristatin F (MMAF), an anti-tubulin agent, makes it hydrophobic functionalization and increases cell permeability[1][2].
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N-Methyl-DL-valine | N-Methyl-DL-valine is a valine derivant, is metabolized to cysteine, alanine, tyrosine, tryptophan, citric acid, and succinic acid in the sprout. N-Methyl-DL-valine involves in the modification of monomethyl auristatin F (MMAF), an anti-tubulin agent, makes it hydrophobic functionalization and increases cell permeability. | |||||||||||||||||||||
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References
- [1]. M. Pasteels, et al. Uptake and metabolism of [14C]rinderine and [14C]retronecine in leaf-beetles of the genus Platyphora and alkaloid accumulation in the exocrine defensive secretions. Chemoecology. 2003;13:55–62.
- [2]. Philip N Moquist, et al. Novel Auristatins with High Bystander and Cytotoxic Activities in Drug Efflux–positive Tumor Models. Mol Cancer Ther.2021;20(2): 320–328.
