2566503-77-1
Chemical Structure
MAPK ligand 1
- CAS No.: 2566503-77-1
- Formula:C20H13NO3
- Molecular Weight:315.32
InChIKey: MKAYSNJLQIXIGB-UHFFFAOYSA-N
SMILES: OC(C1=CC2=C(NC(C3=CC=CC4=C3C=CC=C4)=CC2=O)C=C1)=O
Biological Activity: MAPK ligand 1 is an apoptosis inducer and Bcl-xL/MAPK ligand that can be used to synthesize the Bcl-xL-targeted PROTAC degrader (HY-176740). MAPK ligand 1 triggers apoptosis through the mitochondrial pathway, MAPK pathway, reduction of mitochondrial membrane potential and elevation of reactive oxygen species levels. MAPK ligand 1 inhibits colony formation and migration of cancer cells, as well as angiogenesis of endothelial cells. MAPK ligand 1 can be used in the research of hepatocellular carcinoma[1].
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MAPK ligand 1 | MAPK ligand 1 is an apoptosis inducer and Bcl-xL/MAPK ligand that can be used to synthesize the Bcl-xL-targeted PROTAC degrader (HY-176740). MAPK ligand 1 triggers apoptosis through the mitochondrial pathway, MAPK pathway, reduction of mitochondrial membrane potential and elevation of reactive oxygen species levels. MAPK ligand 1 inhibits colony formation and migration of cancer cells, as well as angiogenesis of endothelial cells. MAPK ligand 1 can be used in the research of hepatocellular carcinoma. | |||||||||||||||||||||
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