2567456-79-3
Chemical Structure
HS-10375
- CAS No.: 2567456-79-3
- Formula:C33H42BrN6O5P
- Molecular Weight:713.60
InChIKey: ZACLCHHBZSAAQG-SZPZYZBQSA-N
SMILES: [H][C@]12[C@@]([H])(CN(C(CC3)CCN3C(C=C4OC)=C(C)C=C4NC5=NC=C(Br)C(NC6=CC=C7OCCOC7=C6P(C)(C)=O)=N5)C2)COC1
Biological Activity: HS-10375 is a selective EGFR tyrosine kinase inhibitor. HS-10375 inhibits EGFR-19del/T790M/C797S-TK and EGFR-L858R/T790M/C797S-TK in an ATP-competitive manner, with IC50 values of 0.09 nM and 0.08 nM, respectively. HS-10375 exhibits higher inhibitory activity against the proliferation of mutant EGFR cells than wild-type EGFR cells, demonstrating selectivity for mutant EGFR and potentially reducing off-target effects. HS-10375 can be used in research related to non-small cell lung cancer[1].
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HS-10375 | HS-10375 is a selective EGFR tyrosine kinase inhibitor. HS-10375 inhibits EGFR-19del/T790M/C797S-TK and EGFR-L858R/T790M/C797S-TK in an ATP-competitive manner, with IC50 values of 0.09 nM and 0.08 nM, respectively. HS-10375 exhibits higher inhibitory activity against the proliferation of mutant EGFR cells than wild-type EGFR cells, demonstrating selectivity for mutant EGFR and potentially reducing off-target effects. HS-10375 can be used in research related to non-small cell lung cancer. | |||||||||||||||||||||
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