2570470-42-5
Chemical Structure
PROTAC BRD2/BRD4 degrader-1
- CAS No.: 2570470-42-5
- Formula:C39H38N6O9S
- Molecular Weight:766.82
IUPAC Name: N-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)-3-(6-((2-methoxyphenyl)sulfonamido)-1-methyl-2-oxo-1,2-dihydrobenzo[cd]indol-4-yl)propanamide
InChIKey: DCPKSVYPNGBDSB-UHFFFAOYSA-N
SMILES: O=C(NCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCC4=CC5=C(NS(=O)(C6=CC=CC=C6OC)=O)C=CC(N(C)C7=O)=C5C7=C4
Biological Activity: PROTAC BRD2/BRD4 degrader-1 (compound 15) is a potent and selective BET protein BRD4 and BRD2 degrader, connected by ligands for Cereblon and BET. PROTAC BRD2/BRD4 degrader-1 rapidly induces reversible, long-lasting, and unexpectedly selective removal of BRD4 and BRD2 over BRD3. PROTAC BRD2/BRD4 degrader-1 effectively inhibits solid tumors with low cytotoxic effect[1].
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PROTAC BRD2/BRD4 degrader-1 | PROTAC BRD2/BRD4 degrader-1 (compound 15) is a potent and selective BET protein BRD4 and BRD2 degrader, connected by ligands for Cereblon and BET. PROTAC BRD2/BRD4 degrader-1 rapidly induces reversible, long-lasting, and unexpectedly selective removal of BRD4 and BRD2 over BRD3. PROTAC BRD2/BRD4 degrader-1 effectively inhibits solid tumors with low cytotoxic effect. | |||||||||||||||||||||
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