2574508-57-7
2574508-57-7
Chemical Structure
Efprezimod alfa
Synonym(s): MK-7110; CD24 Fc
- CAS No.: 2574508-57-7
- Formula:N/A
- Molecular Weight:(57.74 kDa)
SMILES: [Efprezimod alfa]
Biological Activity: Efprezimod alfa (MK 7110; CD24 Fc) is a humanized CD24-Fc fusion protein. Efprezimod alfa enhances the interaction between CD24 and Siglec-10, thereby regulating the response of innate immune cells to damage-associated molecular patterns, inhibiting the activation of antigen-presenting cells and subsequent inflammatory responses. Efprezimod alfa is applicable to the research of acute graft-versus-host disease and acquired immunodeficiency syndrome[1][2].
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Efprezimod alfa | 99.25% | Efprezimod alfa (MK 7110; CD24 Fc) is a humanized CD24-Fc fusion protein. Efprezimod alfa enhances the interaction between CD24 and Siglec-10, thereby regulating the response of innate immune cells to damage-associated molecular patterns, inhibiting the activation of antigen-presenting cells and subsequent inflammatory responses. Efprezimod alfa is applicable to the research of acute graft-versus-host disease and acquired immunodeficiency syndrome. | ||||||||||||||||||||
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References
- [1]. Magenau J, et al. A phase 2 trial of CD24Fc for prevention of graft-versus-host disease. Blood. 2024 Jan 4;143(1):21-31. [Content Brief]
- [2]. Du R, et al. Is modulation of immune checkpoints on glioblastoma-infiltrating myeloid cells a viable therapeutic strategy?. Neuro Oncol. 2025;27(1):33-49. [Content Brief]
