2579070-02-1
Chemical Structure
β-catenin inhibitory peptoid
- CAS No.: 2579070-02-1
- Formula:C59H72N6O12
- Molecular Weight:1057.24
InChIKey: QNURSWNKRAWMEW-PYHIYFCPSA-N
SMILES: O=C1N(C2=CC(OC)=CC(OC)=C2)CC(N(CC(N(CC(N(CC(N[C@@H](C(N(C1)CCC3=C(C=CC=C3)OC4=CC=CC=C4)=O)C)=O)[C@H](C5=CC=C(C=C5)OC)C)=O)[C@H](C6=CC=C(C=C6)OC)C)=O)CCCOC(C)C)=O
Biological Activity: β-catenin inhibitory peptoid (compound 13) inhibits the β-catenin:TCF interaction with an IC50 of 5.44 µM. β-catenin inhibitory peptoid inhibits both Wnt (IC50 of 0.105 µM) and androgen receptor (AR)-signaling (IC50 of 1.02 µM) in prostate cancer cell lines. β-catenin inhibitory peptoid markedly diminishes cell proliferation of prostate cancer cell lines[1].
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β-catenin inhibitory peptoid | β-catenin inhibitory peptoid (compound 13) inhibits the β-catenin:TCF interaction with an IC50 of 5.44 µM. β-catenin inhibitory peptoid inhibits both Wnt (IC50 of 0.105 µM) and androgen receptor (AR)-signaling (IC50 of 1.02 µM) in prostate cancer cell lines. β-catenin inhibitory peptoid markedly diminishes cell proliferation of prostate cancer cell lines. | |||||||||||||||||||||
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