2580940-76-5
2580940-76-5
Chemical Structure
Dot1L-IN-7
- CAS No.: 2580940-76-5
- Formula:C23H27N9O2
- Molecular Weight:461.52
IUPAC Name: 1-(2-((2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)ethyl)amino)-2-oxoethyl)-N-(4-(tert-butyl)phenyl)-1H-1,2,4-triazole-3-carboxamide
InChIKey: XUVUBPKAABPFHR-UHFFFAOYSA-N
SMILES: CC(C)(C1=CC=C(C=C1)NC(C2=NN(C=N2)CC(NCCN3C=CC4=C3N=CN=C4N)=O)=O)C
Biological Activity: Dot1L-IN-7 (compound 25) is a potent and selective disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 of 1.0 μM. Dot1L-IN-7 selectively killed Mixed Lineage Leukemia (MLL)-AF9 without showing any effect on the growth of E2A-HLF cells[1].
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Dot1L-IN-7 | Dot1L-IN-7 (compound 25) is a potent and selective disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 of 1.0 μM. Dot1L-IN-7 selectively killed Mixed Lineage Leukemia (MLL)-AF9 without showing any effect on the growth of E2A-HLF cells. | |||||||||||||||||||||
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