2581082-16-6
Chemical Structure
c-Met/MEK1/Flt-3-IN-1
- CAS No.: 2581082-16-6
- Formula:C39H36F2N6O5
- Molecular Weight:706.74
IUPAC Name: (E)-4-((4-amino-2-phenylpyrimido[5,4-c]quinolin-5(6H)-ylidene)amino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
InChIKey: WZOYVBPQUSYCDV-UHFFFAOYSA-N
SMILES: COC1=C(C=C2N=CC=C(C2=C1)OC3=C(F)C=C(C=C3)NC(C4=CN(C5=C(C4=O)C=CC=N5)C6=CC=C(C=C6)F)=O)OCCCN7CCN(CC7)C
Biological Activity: Antiproliferative against-3 (comp 33) shows a prominent activity against Hela (IC50 = 0.21 µM), A549 (IC50 = 0.39 µM), and MCF-7 (IC50 = 0.33 µM), respectively. Antiproliferative against-3 (comp 33) also dose dependently induces apoptosis by arresting A549 cells at G1 phase[1].
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c-Met/MEK1/Flt-3-IN-1 | Antiproliferative against-3 (comp 33) shows a prominent activity against Hela (IC50 = 0.21 µM), A549 (IC50 = 0.39 µM), and MCF-7 (IC50 = 0.33 µM), respectively. Antiproliferative against-3 (comp 33) also dose dependently induces apoptosis by arresting A549 cells at G1 phase. | |||||||||||||||||||||
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