2584411-87-8
Chemical Structure
RC574
- CAS No.: 2584411-87-8
- Formula:C18H24OSSe
- Molecular Weight:367.41
IUPAC Name: 2,6-di-tert-butyl-4-(thiophen-2-ylselanyl)phenol
InChIKey: CUSKUKDTRDQWBN-UHFFFAOYSA-N
SMILES: OC1=C(C(C)(C)C)C=C([Se]C2=CC=CS2)C=C1C(C)(C)C
Biological Activity: RC574 is a GPx1 and GPx4 modulator that increases GPx1 protein levels and enzyme activity and protects cells against RSL3-induced GPx4 inactivation and ferroptosis. RC574 inhibits glutamate-induced ferroptosis/oxytosis, mitochondrial superoxide anion production, mitochondrial membrane hyperpolarization, oxidant production, and mitochondrial fragmentation. RC574 protects primary cortical neurons against glutamate challenge and inhibits mitochondrial superoxide anion production while increasing antioxidant enzyme activity. RC574 ameliorates motor-related behavioral deficits and reduces reactive astrocytes in the striatum in a rat model of ischemic stroke. RC574 can be used in research on neurodegenerative diseases and ischemic stroke[1][2].
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RC574 | RC574 is a GPx1 and GPx4 modulator that increases GPx1 protein levels and enzyme activity and protects cells against RSL3-induced GPx4 inactivation and ferroptosis. RC574 inhibits glutamate-induced ferroptosis/oxytosis, mitochondrial superoxide anion production, mitochondrial membrane hyperpolarization, oxidant production, and mitochondrial fragmentation. RC574 protects primary cortical neurons against glutamate challenge and inhibits mitochondrial superoxide anion production while increasing antioxidant enzyme activity. RC574 ameliorates motor-related behavioral deficits and reduces reactive astrocytes in the striatum in a rat model of ischemic stroke. RC574 can be used in research on neurodegenerative diseases and ischemic stroke. | |||||||||||||||||||||
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References
- [1]. Bueno DC, et al. New Probucol Analogues Inhibit Ferroptosis, Improve Mitochondrial Parameters, and Induce Glutathione Peroxidase in HT22 Cells. Molecular neurobiology. 2020 Aug;57(8):3273-3290. [Content Brief]
- [2]. Sharif A, et al. The therapeutic potential of probucol and probucol analogues in neurodegenerative diseases. Translational neurodegeneration. 2024 Jan 22;13(1):6.
