2586047-11-0
2586047-11-0
Chemical Structure
2',3'-cGAMP-C2-PPA
- CAS No.: 2586047-11-0
- Formula:C27H36N10O14P2S2
- Molecular Weight:850.71
InChIKey: IBPLNKRENHFZJM-AYPAWVCOSA-N
SMILES: OC(CCC(C)SSCC[C@H]1[C@]2([H])[C@@](N3C4=C(C(N=C(N4)N)=O)N=C3)([H])O[C@]1([H])COP(O)(O[C@]5([H])[C@@](O[C@](N6C7=NC=NC(N)=C7N=C6)([H])[C@@H]5O)([H])COP(O)(O2)=O)=O)=O
Biological Activity: 2’,3’-cGAMP-C2-PPA is a cyclic dinucleotide interferon gene-stimulating protein (STING) agonist. 2’,3’-cGAMP-C2-PPA is a drug conjugated conjugate used to target antibody-drug conjugated conjugate (ADC) for the treatment of cancer. 2’,3’-cGAMP-C2-PPA can be used in the study of immune and tumor-related diseases[1][2][3].
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2',3'-cGAMP-C2-PPA | 2’,3’-cGAMP-C2-PPA is a cyclic dinucleotide interferon gene-stimulating protein (STING) agonist. 2’,3’-cGAMP-C2-PPA is a drug conjugated conjugate used to target antibody-drug conjugated conjugate (ADC) for the treatment of cancer. 2’,3’-cGAMP-C2-PPA can be used in the study of immune and tumor-related diseases. | |||||||||||||||||||||
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References
- [1]. Chen Z, et, al. Antibody-sting agonist conjugates and their use in immunotherapy. US20210015941A1.
- [2]. Stazzoni S, et al. Novel Poxin Stable cGAMP-Derivatives Are Remarkable STING Agonists. Angew Chem Int Ed Engl. 2022 Oct 4;61(40):e202207175. [Content Brief]
- [3]. Zhang X, et al GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell. 2013 Jul 25;51(2):226-35 [Content Brief]
