2586195-28-8
Chemical Structure
Androgen receptor antagonist 5
- CAS No.: 2586195-28-8
- Formula:C21H15F4N5O3S
- Molecular Weight:493.43
IUPAC Name: ethyl (2-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-fluoro-1-oxo-3-thioxo-1,2,3,5,10,10a-hexahydroimidazo[1,5-b]isoquinolin-7-yl)carbamate
InChIKey: UNBRRZQUTMYFAT-UHFFFAOYSA-N
SMILES: CCOC(NC1=CC2=C(CC3C(N(C(N3C2)=S)C4=CC(C(F)(F)F)=C(N=C4)C#N)=O)C=C1F)=O
Biological Activity: Androgen receptor antagonist 5 (compound 42f) is a potent androgen receptor (AR) antagonist with an IC50 value of 6.17 μM. Androgen receptor antagonist 5 can effectively impair AR nuclear translocation, reducing the levels of nuclear AR, and disrupts AR-mediated gene regulation. Androgen receptor antagonist 5 has antiproliferative activity against LNCaP and exhibits antitumor activity in LNCaP xenograft tumor mice model. Androgen receptor antagonist 5 can be used for researching prostate cancer[1].
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Androgen receptor antagonist 5 | Androgen receptor antagonist 5 (compound 42f) is a potent androgen receptor (AR) antagonist with an IC50 value of 6.17 μM. Androgen receptor antagonist 5 can effectively impair AR nuclear translocation, reducing the levels of nuclear AR, and disrupts AR-mediated gene regulation. Androgen receptor antagonist 5 has antiproliferative activity against LNCaP and exhibits antitumor activity in LNCaP xenograft tumor mice model. Androgen receptor antagonist 5 can be used for researching prostate cancer. | |||||||||||||||||||||
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