2592397-70-9
2592397-70-9
Chemical Structure
seco-CBI dimer
- CAS No.: 2592397-70-9
- Formula:C41H36Cl2N4O5
- Molecular Weight:735.65
InChIKey: CIMKIKXWLXTGDA-XFDZPXBPSA-N
SMILES: ClC[C@@H]1CN(C2=C1C3=C(C(O)=C2)C=CC=C3)C(/C=C/C4=C(C=C(C=C4)/C=C/C(N5C6=C([C@@H](C5)CCl)C7=C(C(O)=C6)C=CC=C7)=O)NC(CCN)=O)=O
Biological Activity: seco-CBI dimer is a DNA alkylating agent and a prodrug of Duocarmycin, which can serve as a payload for synthesizing antibody-drug conjugates (ADCs). seco-CBI dimer binds to the minor groove of A-T-rich regions in DNA, alkylates the N3 position of adenine residues, and induces DNA strand breaks. seco-CBI dimer can be used in the research of non-Hodgkin's lymphoma[1].
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seco-CBI dimer | seco-CBI dimer is a DNA alkylating agent and a prodrug of Duocarmycin, which can serve as a payload for synthesizing antibody-drug conjugates (ADCs). seco-CBI dimer binds to the minor groove of A-T-rich regions in DNA, alkylates the N3 position of adenine residues, and induces DNA strand breaks. seco-CBI dimer can be used in the research of non-Hodgkin's lymphoma. | |||||||||||||||||||||
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