260443-89-8
Chemical Structure
5F-203
Synonym(s): NSC-703786
- CAS No.: 260443-89-8
- Formula:C14H11FN2S
- Molecular Weight:258.32
IUPAC Name: 4-(5-fluorobenzo[d]thiazol-2-yl)-2-methylaniline
InChIKey: IFWLHIIUGSEKKE-UHFFFAOYSA-N
SMILES: NC1=CC=C(C2=NC3=CC(F)=CC=C3S2)C=C1C
Biological Activity: 5F-203 (NSC-703786) is an aryl hydrocarbon receptor (AhR) agonist and the active moiety of the water-soluble benzothiazole prodrug Phortress (HY-103223). 5F-203 binds to cytosolic AhR and induces CYP1A1 and CYP1B1 expression. 5F-203 activates AhR signaling to induce DNA damage, cell cycle arrest, apoptosis, caspase-3/-7 activation, lysosomal membrane permeabilization, and Cathepsin B release. 5F-203 induces CYGB and pro-apoptotic protein expression and NAG-1 mRNA/protein induction through RNA stabilization. 5F-203 is used in research related to cancers such as triple-negative breast cancer and colorectal cancer[1][2][3][4][5].
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5F-203 | 98.04% | 5F-203 (NSC-703786) is an aryl hydrocarbon receptor (AhR) agonist and the active moiety of the water-soluble benzothiazole prodrug Phortress (HY-103223). 5F-203 binds to cytosolic AhR and induces CYP1A1 and CYP1B1 expression. 5F-203 activates AhR signaling to induce DNA damage, cell cycle arrest, apoptosis, caspase-3/-7 activation, lysosomal membrane permeabilization, and Cathepsin B release. 5F-203 induces CYGB and pro-apoptotic protein expression and NAG-1 mRNA/protein induction through RNA stabilization. 5F-203 is used in research related to cancers such as triple-negative breast cancer and colorectal cancer. | ||||||||||||||||||||
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5F-203 (Standard) | ≥98% | 5F-203 (Standard) (NSC-703786 (Standard)) is the analytical standard of 5F-203 (HY-124421). This product is intended for research and analytical applications. 5F-203 (NSC-703786) is an aryl hydrocarbon receptor (AhR) agonist and the active moiety of the water-soluble benzothiazole prodrug Phortress (HY-103223). 5F-203 binds to cytosolic AhR and induces CYP1A1 and CYP1B1 expression. 5F-203 activates AhR signaling to induce DNA damage, cell cycle arrest, apoptosis, caspase-3/-7 activation, lysosomal membrane permeabilization, and Cathepsin B release. 5F-203 induces CYGB and pro-apoptotic protein expression and NAG-1 mRNA/protein induction through RNA stabilization. 5F-203 is used in research related to cancers such as triple-negative breast cancer and colorectal cancer. | ||||||||||||||||||||
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References
- [1]. Peters G, et al. The role of pharmacology in anticancer drug development. ADMET and DMPK. 2018 Mar 25;6(1):4-14.
- [2]. Rowland LK, et al. Putative tumor suppressor cytoglobin promotes aryl hydrocarbon receptor ligand-mediated triple negative breast cancer cell death. Journal of cellular biochemistry. 2019 Apr;120(4):6004-6014.
- [3]. Ohashi T, et al. ZSTK3744, a Novel Aryl Hydrocarbon Receptor Agonist, Exhibits Efficacy against Chemotherapy-Resistant Triple-Negative Breast Cancer. Cancer research communications. 2026 Feb 01;6(2):421-436. [Content Brief]
- [4]. Baek SJ, et al. Changes in gene expression contribute to cancer prevention by COX inhibitors. Progress in lipid research. 2006 Jan;45(1):1-16.
- [5]. Eling TE, et al. NSAID activated gene (NAG-1), a modulator of tumorigenesis. Journal of biochemistry and molecular biology. 2006 Nov 30;39(6):649-55.
