2607-56-9
2607-56-9
Chemical Structure
Archangelicin
- CAS No.: 2607-56-9
- Formula:C24H26O7
- Molecular Weight:426.46
IUPAC Name: 2-((8S,9R)-9-(((Z)-2-methylbut-2-enoyl)oxy)-2-oxo-8,9-dihydro-2H-furo[2,3-h]chromen-8-yl)propan-2-yl (Z)-2-methylbut-2-enoate
InChIKey: RVGGCRQPGKFZDS-AKRYRNCVSA-N
SMILES: C/C=C(C)\C(O[C@H]1[C@@H](C(OC(/C(C)=C\C)=O)(C)C)OC(C=C2)=C1C(O3)=C2C=CC3=O)=O
Biological Activity: Archangelicin is an inhibitor for cAMP-phosphodiesterase (cAMP-PDE) with IC50 >400 μM. Archangelicin inhibits nuclear factor of activated T cell (NFAT) with IC50 of 9 μM. Archangelicin exhibits antitumor and anti-inflammatory[1][2][3].
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Archangelicin | Archangelicin is an inhibitor for cAMP-phosphodiesterase (cAMP-PDE) with IC50 >400 μM. Archangelicin inhibits nuclear factor of activated T cell (NFAT) with IC50 of 9 μM. Archangelicin exhibits antitumor and anti-inflammatory. | |||||||||||||||||||||
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References
- [1]. Okuyama T, et al., Anti-tumor-promotion by principles obtained from Angelica keiskei. Planta Med. 1991 Jun;57(3):242-6. [Content Brief]
- [2]. Thastrup O, et al., Inhibition of human platelet aggregation by dihydropyrano- and dihydrofuranocoumarins, a new class of cAMP-phosphodiesterase inhibitors. Biochem Pharmacol. 1985 Jun 15;34(12):2137-40. [Content Brief]
- [3]. Nagasawa A, et al. Angular-type Furocoumarins from the Roots of Angelica atropurpurea and their Inhibitory Activity on the NFAT Signal Transduction Pathway[J]. Natural Product Communications, 2014, 9(12): 1934578X1400901218.
