2615173-24-3
2615173-24-3
Chemical Structure
Lck-IN-2
- CAS No.: 2615173-24-3
- Formula:C31H32N8O5
- Molecular Weight:596.64
InChIKey: ISBWZUCWSZVLJT-UHFFFAOYSA-N
SMILES: CC1=CC=C(C=C1N2CC3=C(N(C2=O)C)N=C(N=C3)NC4=CN=C(C=C4)C)NC(C5=CC=C(C(OCC(C)C)=C5)[N+]([O-])=O)=O
Biological Activity: Lck-IN-2 (compound 12a) is an inhibitor of Lymphocyte-specific protein tyrosine kinase (Lck) with IC50 of 10.6 nM. Lck-IN-2 reveals efficacy in colon cancer cells with GI50s of 0.24-1.26 μM. Lck-IN-2 exhibits an apoptotic effect in Colo201 cells[1].
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Lck-IN-2 | Lck-IN-2 (compound 12a) is an inhibitor of Lymphocyte-specific protein tyrosine kinase (Lck) with IC50 of 10.6 nM. Lck-IN-2 reveals efficacy in colon cancer cells with GI50s of 0.24-1.26 μM. Lck-IN-2 exhibits an apoptotic effect in Colo201 cells. | |||||||||||||||||||||
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