2630989-02-3
Chemical Structure
HDAC1/6-IN-1
- CAS No.: 2630989-02-3
- Formula:C32H45N7O4
- Molecular Weight:591.74
IUPAC Name: 6-(4-(4-((1-benzylpiperidin-4-yl)amino)-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)-N-hydroxyhexanamide
InChIKey: VSEYIEDVOXUHFM-UHFFFAOYSA-N
SMILES: COC1=C(C=C2C(N=C(N=C2NC3CCN(CC3)CC4=CC=CC=C4)N5CCN(CC5)CCCCCC(NO)=O)=C1)OC
Biological Activity: HDAC1/6-IN-1 (compound D7) is a potent multitarget inhibitor of GLP, HDAC6 and HDAC1, with IC50 values of 1.3, 13, and 89 nM, respectively. HDAC1/6-IN-1 can inhibit the methylation and deacetylation of H3K9 on protein level. HDAC1/6-IN-1 induces cancer cell apoptosis, G0/G1 cell cycle arrest, and blocks migration and invasion[1].
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HDAC1/6-IN-1 | HDAC1/6-IN-1 (compound D7) is a potent multitarget inhibitor of GLP, HDAC6 and HDAC1, with IC50 values of 1.3, 13, and 89 nM, respectively. HDAC1/6-IN-1 can inhibit the methylation and deacetylation of H3K9 on protein level. HDAC1/6-IN-1 induces cancer cell apoptosis, G0/G1 cell cycle arrest, and blocks migration and invasion. | |||||||||||||||||||||
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