2636771-29-2
2636771-29-2
Chemical Structure
PKC-IN-4
- CAS No.: 2636771-29-2
- Formula:C21H25N5S
- Molecular Weight:379.52
IUPAC Name: (1-(2-(pyridin-4-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)piperidin-4-yl)methanamine
InChIKey: TXGUECVFNFKTBD-UHFFFAOYSA-N
SMILES: NCC1CCN(CC1)C2=NC(C3=CC=NC=C3)=NC4=C2C5=C(S4)CCCC5
Biological Activity: PKC-IN-4 (compound 7l) is a potent and orally active aPKC inhibitor with an IC50 of 0.52 µM. PKC-IN-4 inhibits TNF-α induced NF-κB activity in vitro. PKC-IN-4 blocks VEGF- and TNFα-induced permeability across the retinal vasculature[1].
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PKC-IN-4 | PKC-IN-4 (compound 7l) is a potent and orally active aPKC inhibitor with an IC50 of 0.52 µM. PKC-IN-4 inhibits TNF-α induced NF-κB activity in vitro. PKC-IN-4 blocks VEGF- and TNFα-induced permeability across the retinal vasculature. | |||||||||||||||||||||
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