2640054-39-1
Chemical Structure
Antifungal agent 22
- CAS No.: 2640054-39-1
- Formula:C21H26Cl3NOS
- Molecular Weight:446.86
IUPAC Name: 7-(3,4-dichlorophenyl)-N-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine hydrochloride
InChIKey: ZARZBTBMGXXGGC-UHFFFAOYSA-N
SMILES: ClC1=CC(C2C3=C(C(CC2)NCCC4CCOCC4)C=CS3)=CC=C1Cl.[H]Cl
Biological Activity: Antifungal agent 22 (compound D16) is a potential and orally active antifungal agent for CM (cryptococcal meningitis), with an IC50 of 0.5 μg/mL. Antifungal agent 22 can penetrate the blood-brain barrier and kill the C. neoformans H99 cells by destroying the integrity of fungal cell membranes. Antifungal agent 22 shows selective anti-Cryptococcus activity with good metabolic stability and low cytotoxicity[1].
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Antifungal agent 22 | Antifungal agent 22 (compound D16) is a potential and orally active antifungal agent for CM (cryptococcal meningitis), with an IC50 of 0.5 μg/mL. Antifungal agent 22 can penetrate the blood-brain barrier and kill the C. neoformans H99 cells by destroying the integrity of fungal cell membranes. Antifungal agent 22 shows selective anti-Cryptococcus activity with good metabolic stability and low cytotoxicity. | |||||||||||||||||||||
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