2640089-88-7
2640089-88-7
Chemical Structure
INCB126503
- CAS No.: 2640089-88-7
- Formula:C27H30N6O2
- Molecular Weight:470.57
SMILES: CC1=CC=CC(C2=NC3=C(NN=C3C4=CN=C(N5C[C@@](C[C@@H](O)C6)([H])N6CC5)C=C4)C=C2OC)=C1C
Biological Activity: INCB126503 is an orally activeM, selective FGFR2/3 Inhibitor with IC50 values of 70 nM (FGFR1), 2.1 nM (FGFR2), 1.2 nM (FGFR3), 0.92 nM (FGFR3-V555L), 0.85 nM (FGFR3-V555M) and 64 nM (FGFR4). INCB126503 suppresses FGFR signaling in vivo without causing hyperphosphatemia and shows antitumor efficacy in xenograft models harboring FGFR3 genetic alterations[1].
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INCB126503 | INCB126503 is an orally activeM, selective FGFR2/3 Inhibitor with IC50 values of 70 nM (FGFR1), 2.1 nM (FGFR2), 1.2 nM (FGFR3), 0.92 nM (FGFR3-V555L), 0.85 nM (FGFR3-V555M) and 64 nM (FGFR4). INCB126503 suppresses FGFR signaling in vivo without causing hyperphosphatemia and shows antitumor efficacy in xenograft models harboring FGFR3 genetic alterations. | |||||||||||||||||||||
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