2648548-71-2
Chemical Structure
EA-RK-110
- CAS No.: 2648548-71-2
- Formula:C23H32F3N5O
- Molecular Weight:451.53
InChIKey: PPQCJBGNDPIZOE-IRJFHVNHSA-N
SMILES: CN(C)C(N[C@@H](CC1)CC[C@H]1CCN(CC2)CCN2C3=CC(C#N)=CC(C(F)(F)F)=C3)=O
Biological Activity: EA-RK-110 is a dopamine D3 receptor inverse agonist derived from Cariprazine (HY-14763) that stabilizes the inactive conformation and attenuates G protein signaling. EA-RK-110 weakly activates dopamine D2 receptor-mediated signaling. EA-RK-110 mediates inverse agonism through its meta-nitrile group via receptor residue interactions and toggle-switch modulation. EA-RK-110 can be used for research on dopamine receptor-related diseases[1].
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EA-RK-110 | EA-RK-110 is a dopamine D3 receptor inverse agonist derived from Cariprazine (HY-14763) that stabilizes the inactive conformation and attenuates G protein signaling. EA-RK-110 weakly activates dopamine D2 receptor-mediated signaling. EA-RK-110 mediates inverse agonism through its meta-nitrile group via receptor residue interactions and toggle-switch modulation. EA-RK-110 can be used for research on dopamine receptor-related diseases. | |||||||||||||||||||||
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