2649170-17-0
2649170-17-0
Chemical Structure
TLR7/8 agonist 9
- CAS No.: 2649170-17-0
- Formula:C20H26N6O
- Molecular Weight:366.46
IUPAC Name: 6-(4-((dimethylamino)methyl)benzyl)-N4-(2-methoxyethyl)pyrido[3,2-d]pyrimidine-2,4-diamine
InChIKey: UQHYCVOVYJQJOY-UHFFFAOYSA-N
SMILES: NC1=NC(NCCOC)=C2C(C=CC(CC3=CC=C(CN(C)C)C=C3)=N2)=N1
Biological Activity: TLR7/8 agonist 9 (Compound 25a) is a TLR7/8 agonist, with EC50s of 40 nM and 23 nM for hTLR7/8. TLR7/8 agonist 9 has anti-tumor activity and improves the antitumor activity of PD-1/PD-L1 blockade. TLR7/8 agonist 9 can be used for research of cancer immunotherapy[1].
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TLR7/8 agonist 9 | TLR7/8 agonist 9 (Compound 25a) is a TLR7/8 agonist, with EC50s of 40 nM and 23 nM for hTLR7/8. TLR7/8 agonist 9 has anti-tumor activity and improves the antitumor activity of PD-1/PD-L1 blockade. TLR7/8 agonist 9 can be used for research of cancer immunotherapy. | |||||||||||||||||||||
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