2649762-09-2
2649762-09-2
Chemical Structure
LK-2
- CAS No.: 2649762-09-2
- Formula:C12H17N2O5P
- Molecular Weight:300.25
InChIKey: IQVRRMXXZQMFLA-UHFFFAOYSA-N
SMILES: OP(C(C1=CC=CC=C1)N2CC(C(O)=O)NCC2)(O)=O
Biological Activity: LK-2 is an antagonist for ASIC1a with a Kd of 1.9 μM. LK-2 reduces glutamate-induced ASIC1a current-enhancement with an IC50 of 6.6 μM. LK-2 exhibits neuroprotective efficacy in mouse ischemic stroke model, with improved motor and coordination skills. LK-2 is blood-brain barrier (BBB) penetrable[1].
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LK-2 | 98.83% | LK-2 is an antagonist for ASIC1a with a Kd of 1.9 μM. LK-2 reduces glutamate-induced ASIC1a current-enhancement with an IC50 of 6.6 μM. LK-2 exhibits neuroprotective efficacy in mouse ischemic stroke model, with improved motor and coordination skills. LK-2 is blood-brain barrier (BBB) penetrable. | ||||||||||||||||||||
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